📄 Category

psychiatry and clinical psychology

146 papers

Understanding the human mind and treating mental health conditions requires a deep blend of biological insight and behavioral science. This category explores the cutting-edge research shaping how we diagnose and treat psychiatric disorders, from depression and anxiety to complex neurological conditions. Here, you will find the latest discoveries that bridge the gap between clinical observation and molecular mechanisms, offering fresh perspectives on patient care and therapeutic innovation.

Gist.Science brings these vital studies directly to you by monitoring medRxiv, the leading preprint server for health sciences. As soon as new manuscripts appear in this field, our team processes them to provide both accessible plain-language summaries and detailed technical overviews. This ensures that complex findings are understandable for everyone, from curious readers to busy professionals who need quick, accurate insights without wading through dense academic prose.

Below are the most recent psychiatry and clinical psychology preprints, curated and summarized to keep you informed on the evolving landscape of mental health research.

📄 psychiatry and clinical psychology

Nigerian language as a contextual moderator of trauma-related PTSD and CPTSD among Liberian and Sierra Leonean refugee children in Oru Refugee Camp: A social-ecological moderation model of refugee children's trauma

This study reveals that while witnessed and physical trauma strongly predict PTSD and functional impairment among stateless refugee children in Nigeria, emotional and sexual trauma specifically drive CPTSD symptoms, with the protective effect of teacher support against self-organization disturbances being significantly contingent on the children's proficiency in the Nigerian language.

Yarseah, D. A., Ibimiluyi,, O. F., Ogunsanmi, O., Omojola, A. O., Flomo, J. M. N., Fatai, B. F., Olaoye, E. O., Adesola (…)2026-03-12
📄 psychiatry and clinical psychology

Connectivity within the Hippocampus as a Neural Marker of Early Clinical Trajectories in the Psychosis Risk State

This study identifies decreasing intra-hippocampal connectivity as a specific, prognostic neural marker that precedes and predicts the worsening of negative symptoms and functional decline in individuals at clinical high risk for psychosis.

Roell, L., Lindner, C., Tian, Y. E., Chopra, S., Maurus, I., Moussiopoulou, J., Yakimov, V., Korman, M., Keeser, D., Sch (…)2026-03-11
📄 psychiatry and clinical psychology

Patterns of depression prevalence and antidepressant use in South Africa, 2002-2024: a system dynamics modelling perspective

Using a system dynamics model calibrated to national survey data, this study reveals that while depression prevalence in South Africa has remained relatively stable from 2002 to 2024, antidepressant use remains low overall with a stark disparity between the private and public health sectors.

Johnson, L. F., Giovenco, D., Eyal, K., Craig, A., Petersen, I., Tlali, M., Levitt, N. S., Bachmann, M., Haas, A. D., Fa (…)2026-03-09
📄 psychiatry and clinical psychology

Circadian-related hypothalamic structure differs by chronotype in bipolar disorder

Using UK Biobank data, this study reveals that individuals with bipolar disorder who have an evening chronotype exhibit significantly larger volumes in the circadian-regulating anterior-inferior hypothalamic region compared to their morning chronotype counterparts, a structural difference not observed in other psychiatric diagnoses or hypothalamic subunits.

Tahedl, M., Rohrer, J., Seifritz, E., Smith, D. J., Homan, P.2026-03-07
📄 psychiatry and clinical psychology

Acceptability of cannabidiol as a treatment for people at clinical high risk for psychosis

A survey of 55 individuals at clinical high risk for psychosis found that cannabidiol (CBD) is a highly acceptable treatment option, with most participants familiar with the compound, willing to use it, and anticipating fewer side effects compared to existing medications.

Oliver, D., Chesney, E., Wallman, P., Estrade, A., Azis, M., Provenzani, U., Damiani, S., Melillo, A., Hunt, O., Agarwal (…)2026-03-06
📄 psychiatry and clinical psychology

Regional blood flow signatures of opioidergic modulation of ketamine in major depressive disorder: a randomised crossover study

This randomized crossover study demonstrates that while naltrexone does not block ketamine-induced increases in regional cerebral blood flow in major depressive disorder, it disrupts the associations between these hemodynamic changes and both subjective effects and antidepressant response, suggesting that opioidergic modulation interacts with glutamatergic and GABAergic systems to influence ketamine's therapeutic mechanisms.

Jelen, L. A., O'Daly, O., Zelaya, F. O., Stone, J. M., Young, A. H., Mehta, M. A.2026-03-05
📄 psychiatry and clinical psychology

Estimated Head Motion Contributes to Case-Control Magnetic Resonance Imaging Morphometry Differences in Schizophrenia

This study demonstrates that in-scanner head motion is a significant confounding factor in structural MRI analyses of schizophrenia, accounting for a substantial portion of observed grey matter differences between patients and controls and suggesting that many reported morphometric findings may be motion-driven artifacts rather than true tissue properties.

Passiatore, R., Sambuco, N., Stolfa, G., Antonucci, L. A., Bertolino, A., Blasi, G., Fazio, L., Goldman, A. L., Grassi (…)2026-03-05
📄 psychiatry and clinical psychology

Data-driven profiles of psychosis stages reveal distinct and overlapping clinical, cognitive, and neuroanatomical phenotypes

This study utilizes a unique multimodal dataset to demonstrate that while affective and functional disturbances emerge in early psychosis stages, cognitive and neuroanatomical abnormalities characterize more advanced phases, yet significant overlapping phenotypes across risk groups underscore the need for personalized care beyond traditional diagnostic boundaries.

Danyluik, M., Ghanem, J., Bedford, S. A., Aversa, S., Leclercq, A., Proteau-Fortin, F., Eid, J., Ibrahim, F., Morvan, M. (…)2026-03-05
📄 psychiatry and clinical psychology

No evidence of increased gaming-related problems with long-term use of a video game therapeutic: Exploratory endpoint findings from a randomized controlled trial

This randomized controlled trial demonstrates that long-term use of the video game therapeutic Meliora for major depressive disorder does not increase gaming-related problems, even with high engagement or immersion, supporting the safety of video games as a medium for digital therapeutics.

Lukka, L., Juvonen, J. J., Palva, S., Isometsä, E., Palva, J. M.2026-03-05
📄 psychiatry and clinical psychology

A tool to evaluate the impact of lived experience involvement in research: the Brain and Genomics Hub: Impact Log literature review and protocol.

This paper presents a protocol and literature review for the "Impact Log," a novel, lived-experience-led tool and framework designed to systematically record, evaluate, and enhance the impact of co-production across all stages of the Brain and Genomics Hub's multidisciplinary research on severe mental illness.

Gergel, T., Wright, T., Geshica, L., Vicary, E., Kennett, J., Delgaram-Nejad, O., Edwards, C., Ganesh, H., Kabir, T., Ha (…)2026-03-04